From a winery started by two brothers who immigrated from Italy in the mid-1800s, later passed down to Giuseppe's 18-year-old daughter Isabelle Simi who became a female pioneer in the wine industry, leading the business through prohibition, SIMI is now one of Sonoma's longest-standing institutions. 'Wine is all about the nose, and putting it to the grindstone.' Isabelle Simi knew this better than anyone. She steered the winery with defiant determination for over 70 years, persevering to better

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